Prothena/$PRTA
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About Prothena
Prothena Corp PLC is a clinical biotechnology company that focuses on protein dysregulation and a pipeline of investigational therapeutics with the potential to change the course of devastating neurodegenerative and rare and peripheral amyloid diseases. The company's clinical pipeline of antibody-based product candidates targets a range of indications, including Amyloid Light-chain (AL) amyloidosis (NEOD001), Parkinson's disease and other related synucleinopathies (PRX002), and inflammatory diseases, including ATTR amyloidosis [Coramitug (PRX004)], Alzheimer's disease (PRX123), Neurodegeneration (PRXPRX019), and Others.
Ticker
$PRTA
Sector
Primary listing
Employees
163
Headquarters
Dublin, Ireland
Website
Prothena Metrics
BasicAdvanced
$531M
-
-$5.63
-0.04
-
Price and volume
Market cap
$531M
Beta
-0.04
52-week high
$18.00
52-week low
$4.32
Average daily volume
856K
Financial strength
Current ratio
5.685
Quick ratio
5.478
Long term debt to equity
2.136
Total debt to equity
3.016
Profitability
EBITDA (TTM)
-248.103
Gross margin (TTM)
-1,758.84%
Net profit margin (TTM)
-2,929.30%
Operating margin (TTM)
-2,407.87%
Effective tax rate (TTM)
-15.76%
Revenue per employee (TTM)
$60,000
Management effectiveness
Return on assets (TTM)
-29.79%
Return on equity (TTM)
-66.85%
Valuation
Price to revenue (TTM)
51.312
Price to book
1.64
Price to tangible book (TTM)
1.64
Price to free cash flow (TTM)
-2.752
Free cash flow yield (TTM)
-36.34%
Free cash flow per share (TTM)
-3.583
Growth
Revenue change (TTM)
-95.24%
Earnings per share change (TTM)
492.43%
3-year revenue growth (CAGR)
-58.32%
10-year revenue growth (CAGR)
9.00%
3-year earnings per share growth (CAGR)
420.95%
10-year earnings per share growth (CAGR)
10.28%
What the Analysts think about Prothena
Analyst ratings (Buy, Hold, Sell) for Prothena stock.
Bulls say / Bears say
Roche plans to advance prasinezumab, the anti-alpha-synuclein antibody licensed from Prothena, into Phase 3 trials for early-stage Parkinson’s disease by the end of 2025, backing the program after encouraging data from the Phase IIb PADOVA study (Roche)
The FDA has cleared the IND and granted Fast Track status to PRX123, Prothena’s dual Aβ/tau vaccine for Alzheimer’s disease, speeding up its clinical development (Business Wire)
Prothena finished Q2 2025 with $372.3 million in cash and restricted cash, ensuring sufficient capital to support ongoing trials and strategic plans into 2026 (Business Wire)
The Phase 3 AFFIRM-AL trial for birtamimab failed to achieve both its main and secondary goals, leading Prothena to end the program and lay off about 63% of its workforce as a cash-conservation measure (Business Wire)
Prothena’s GAAP revenue for the second quarter of 2025 plunged 96.7% from a year prior to $4.4 million, highlighting its lack of approved products and dependence on milestone payments from partners (Nasdaq)
In Q2 2025, Prothena recorded a GAAP net loss per share of $2.34, influenced by a $32.6 million restructuring charge, pointing to high cash burn and ongoing earnings volatility (Business Wire)
Data summarised monthly by Lightyear AI. Last updated on 3 Oct 2025.
Prothena Financial Performance
Revenues and expenses
Prothena Earnings Performance
Company profitability
Prothena News
AllArticlesVideos

Prothena's Partner Bristol Myers Squibb Obtains Fast Track Designation from the U.S. FDA for BMS-986446 (PRX005), an Anti-MTBR-Tau-Targeting Antibody, for the Treatment of Alzheimer's Disease
Business Wire6 days ago

Prothena to Participate in the Cantor Fitzgerald Global Healthcare Conference
Business Wire1 month ago
Data displayed above is indicative only and its accuracy or completeness is not guaranteed. Actual execution price may vary. Past performance is not indicative of future results. Your return may be affected by currency fluctuations and applicable fees and charges. Capital at risk.
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Capital at risk
Upcoming events
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FAQs
What’s the current market cap for Prothena stock?
Prothena (PRTA) has a market cap of $531M as of October 07, 2025.
What is the P/E ratio for Prothena stock?
The price to earnings (P/E) ratio for Prothena (PRTA) stock is 0 as of October 07, 2025.
Does Prothena stock pay dividends?
No, Prothena (PRTA) stock does not pay dividends to its shareholders as of October 07, 2025.
When is the next Prothena dividend payment date?
Prothena (PRTA) stock does not pay dividends to its shareholders.
What is the beta indicator for Prothena?
Prothena (PRTA) has a beta rating of -0.04. This means that it has an inverse relation to market volatility.