Aeglea BioTherapeutics, Inc./$SYRE

Spyre Therapeutics jumps after announcing at UEGW 2025 six-month follow-up Phase 1 SPY002 data showing durable target suppression and favorable safety and PK profiles.
12 hours agoLightyear AI
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About Aeglea BioTherapeutics, Inc.

Spyre Therapeutics Inc is a biotechnology company that aims to create the next-generation of inflammatory bowel disease (IBD) products by combining antibody engineering, rational therapeutic combinations, and precision medicine approaches for patient selection. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders which are UC and CD. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.

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$SYRE
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Employees

87

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$968M
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-$2.85
2.83
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Extended follow-up Phase 1 results for SPY001 presented at DDW 2025 showed a good safety profile in all dose groups, a half-life over three times longer than vedolizumab—supporting potential maintenance dosing every six months—and rapid, sustained α4β7 receptor saturation for more than six months. This allowed progression to a Phase 2 UC trial scheduled for mid-2025 (Nasdaq)
As of March 31, 2025, Spyre reported $565 million in cash, cash equivalents, and marketable securities, providing funding into the second half of 2028 to support multiple clinical milestones (Nasdaq)
Within nine months, Spyre launched four separate Phase 1 trials (SPY001, two SPY002 candidates, and SPY003) and now has fully funded Phase 2 trials planned that are expected to yield over seven proof-of-concept readouts in markets worth approximately $50 billion yearly, highlighting strong pipeline execution (Nasdaq)
The 2025 Q2 10-Q warns that if Spyre and the FDA or other regulators do not agree on the trial design or timelines for SKYWAY-RD and SKYLINE-UC, this could lead to higher costs or delays, which would have a material impact on the business (SEC)
The filing also states that success relies on achieving in humans the prolonged half-lives seen in non-human primates; if future trials fail to replicate these results, the clinical and commercial prospects would be seriously undermined (SEC)
In August 2025, Spyre’s Compensation Committee awarded inducement stock options for 60,400 shares to five non-executive employees under the 2018 Equity Inducement Plan, which could dilute current shareholders (GlobeNewswire)
Data summarised monthly by Lightyear AI. Last updated on 4 Oct 2025.
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