Upstream Bio, Inc./$UPB

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About Upstream Bio, Inc.

Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.

Ticker

$UPB
Sector
Primary listing

Employees

52

UPB Metrics

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$1B
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-$3.02
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Bulls say / Bears say

Upstream Bio expanded its clinical pipeline into a third major respiratory indication by dosing the first patient in its global Phase 2 VENTURE trial for verekitug in moderate-to-severe COPD, diversifying its development risk beyond CRSwNP and severe asthma.
With $393.6 million in cash and short-term investments as of June 30, 2025, Upstream Bio has secured funding through 2027, reducing near-term financing risk while advancing multiple Phase 2 programs.
Quantitative pharmacology modeling data presented at the EAACI Congress demonstrated verekitug’s potent and sustained TSLP receptor inhibition, reinforcing its differentiated mechanism and rapid, robust pharmacodynamic profile.
R&D expenses surged 168.8% year-over-year to $37.9 million in Q2 2025, driving net loss to $40 million and accelerating cash burn, which could pressure the company if clinical timelines slip.
As a single-asset company with all programs in Phase 2, Upstream Bio’s valuation is highly dependent on binary trial outcomes; failure in any of the CRSwNP, severe asthma or COPD readouts could severely erode its market value.
Tezepelumab, an approved TSLP inhibitor, has demonstrated a 98% reduction in nasal polyp surgery and an 88% reduction in corticosteroid use in Phase III CRSwNP trials, posing a significant competitive threat to verekitug’s market prospects.
Data summarised monthly by Lightyear AI. Last updated on 5 Oct 2025.
Data displayed above is indicative only and its accuracy or completeness is not guaranteed. Actual execution price may vary. Past performance is not indicative of future results. Your return may be affected by currency fluctuations and applicable fees and charges. Capital at risk.
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