Nuvalent/$NUVL

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About Nuvalent

Nuvalent Inc is a clinical-stage biopharmaceutical company focused on creating precisely targeted therapies for patients with cancer. All of the Company's operations are in the United States. The company is engaged in developing small molecules that are designed to overcome the limitations of existing therapies for clinically validated kinase targets. The product candidates of the company include NVL-520, which is being developed for patients with ROS1-positive non-small cell lung cancer (NSCLC), NVL-655, which is being developed for patients with anaplastic lymphoma kinase (ALK)-positive NSCLC, NVL-330, is a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to address the combined medical need of treating tumors driven by HER2ex20.

Ticker

$NUVL
Sector
Primary listing

Employees

218

Nuvalent Metrics

BasicAdvanced
$7B
-
-$5.32
1.30
-

What the Analysts think about Nuvalent

Analyst ratings (Buy, Hold, Sell) for Nuvalent stock.

Bulls say / Bears say

Nuvalent announced pivotal Phase 1/2 ARROS-1 results with a 44% overall response rate (ORR) and responses lasting up to 18 months in TKI pre-treated ROS1-positive NSCLC, underscoring strong clinical potential for NVL-520.
The company has started a rolling NDA submission for zidesamtinib under the FDA’s Real-Time Oncology Review program, aiming for completion in Q3 2025, which could speed up its time to market.
As of June 30, 2025, Nuvalent had approximately $1.0 billion in cash, cash equivalents, and marketable securities, providing enough funding to operate into 2028 and support late-stage trials without an urgent need for more capital.
Nuvalent's net loss for the second quarter of 2025 widened to $99.7 million (GAAP), showing substantial pre-commercial operating losses and a rising cash burn before any product revenue.
R&D expenses rose sharply to $80.9 million in Q2 2025, up 64.6% year-over-year, which raises concerns over persistently high spending prior to reaching commercialization milestones.
The Phase 3 ALKAZAR trial directly compares NVL-655 with Roche’s alectinib in first-line ALK-positive NSCLC, putting NVL-655 in a tough competitive situation where it must show clear advantages to capture market share.
Data summarised monthly by Lightyear AI. Last updated on 3 Nov 2025.

Nuvalent Financial Performance

Revenues and expenses
QuarterlyAnnual
Q3 24
QoQ growth
Revenue
$37B
-39.75%
Net income
$45B
107.52%
Profit margin
37.65%
6.78%

Nuvalent Earnings Performance

Company profitability
QuarterlyAnnual
Q4 23
Q1 24
Q2 24
Q3 24
Q4 24
Actual
$3.69
$2.85
$2.45
$2.42
-
Expected
$3.55
$2.61
$2.05
$2.31
$3.94
Surprise
3.94%
9.20%
19.51%
4.63%
-
Data displayed above is indicative only and its accuracy or completeness is not guaranteed. Actual execution price may vary. Past performance is not indicative of future results. Your return may be affected by currency fluctuations and applicable fees and charges. Capital at risk.
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